Immunomodulator-Based Enhancement of Anti Smallpox Immune Responses
نویسندگان
چکیده
منابع مشابه
Immunomodulator-Based Enhancement of Anti Smallpox Immune Responses
BACKGROUND The current live vaccinia virus vaccine used in the prevention of smallpox is contraindicated for millions of immune-compromised individuals. Although vaccination with the current smallpox vaccine produces protective immunity, it might result in mild to serious health complications for some vaccinees. Thus, there is a critical need for the production of a safe virus-free vaccine agai...
متن کاملCell-mediated immune responses to smallpox vaccination.
We report that vaccine dilution (1:1 or 1:10) and previous vaccinia virus vaccination status had no significant effect on cell-mediated immune responses (i.e., the immediate vaccinia virus-specific gamma interferon-producing T-cell response measured by enzyme-linked immunospot assay) 1 month after smallpox vaccination (Lancy-Vaxina; Berna Biotech, Switzerland).
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Cellular cooperation between different lymphoid cell populations is a characteristic feature of many immune responses (1, 2). The classes of lymphoid cells which have been shown to collaborate have been divided into two major groups: thymus-derived (T cell) 1 and bone marrow-derived (B cell) lymphocytes. Synergism between T cell and B cell components has been demonstrated for (a) humoral respon...
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Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia and inflammatory diseases. Because anti-HTLV-1 immune responses are critical for suppressing infected cells, enhancing cellular immunity is beneficial for the treatment of HTLV-1-associated diseases. Using simian T-cell leukemia virus type 1 (STLV-1) infected Japanese macaques, we analyzed the immune responses to viral ant...
متن کاملSpecific Heterologous Enhancement of Immune Responses
The mixing of two histoincompatible human lymphocyte cell lines generated the release of a soluble factor which was capable of nonspecifically enhancing the in vitro immune response of normal mouse spleen cells against sheep erythrocytes. When active supernates were subjected to exclusion chromatography on Sephadex G-150 and BioGel P-150, the active principle eluted with molecules of approximat...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0123113